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Related Experiment Video

Updated: Feb 5, 2026

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
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An experimental murine model to study periodontitis.

Julie Marchesan1, Mustafa S Girnary1, Li Jing1

  • 1Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Nature Protocols
|September 16, 2018
PubMed
Summary

A simplified ligature method effectively induces periodontitis in mice, enabling study of gum disease and bone loss. This model aids research into periodontal disease pathogenesis and potential treatments.

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Area of Science:

  • Oral biology and immunology
  • Animal models for disease research

Background:

  • Periodontal disease (PD) is a common inflammatory condition affecting gum tissue and bone, often leading to tooth loss.
  • Understanding PD pathogenesis and developing effective treatments are crucial due to its prevalence.

Purpose of the Study:

  • To present a simplified, reproducible method for inducing periodontitis in mice using a ligature.
  • To demonstrate the utility of this model for studying gingival inflammation and alveolar bone loss.

Main Methods:

  • Development of a simplified technique for placing a bacterially retentive ligature between murine molars.
  • Evaluation of gingival tissue inflammation and alveolar bone loss over 18 days post-ligature placement.

Main Results:

  • The simplified ligature placement method facilitates consistent induction of periodontitis in mice.
  • The model allows for the assessment of key periodontitis indicators, including inflammation and bone resorption.

Conclusions:

  • This protocol offers a technically accessible and effective mouse model for studying periodontal disease pathogenesis.
  • The model is suitable for investigating the role of specific bacteria in PD and for testing therapeutic interventions.