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A Protocol for Computer-Based Protein Structure and Function Prediction
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Predictive Value of [

Bingxin Gu1,2,3,4,5, Shuai Liu1,2,3,4,5, Yuyun Sun1,2,3,4,5

  • 1Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, No. 270, Dong'an Road, Xuhui District, Shanghai, China.

Molecular Imaging and Biology
|September 16, 2018
PubMed
Summary
This summary is machine-generated.

Cetuximab enhances cancer therapy by increasing radiosensitivity and apoptosis. [18F]ML-10 PET/CT imaging shows promise for predicting nasopharyngeal carcinoma treatment response.

Keywords:
CNE-1 cellsEpidermal growth factor receptorNasopharyngeal carcinomaPositron emission tomographyRadiotherapy sensitivity

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Area of Science:

  • Oncology
  • Radiotherapy
  • Molecular Imaging

Background:

  • Apoptosis is a key indicator of successful cancer therapy.
  • Accurate detection of apoptosis aids in managing malignant tumors.
  • Nasopharyngeal carcinoma (NPC) treatment response prediction is crucial.

Purpose of the Study:

  • To investigate the effect of Cetuximab on radiosensitivity and apoptosis in CNE-1 cells.
  • To evaluate [18F]ML-10 and [18F]FDG PET/CT for monitoring treatment response in NPC models.

Main Methods:

  • In vitro studies using CNE-1 cell lines (colony formation, CCK-8, apoptosis assays, Western blotting).
  • In vivo studies with NPC xenografts in nude mice.
  • Small animal PET/CT imaging using [18F]ML-10 and [18F]FDG.
  • Immunohistochemical analysis of EGFR, Ki-67, Glut-1, and TUNEL.

Main Results:

  • Cetuximab significantly increased radiation-induced cytotoxicity and apoptosis in CNE-1 cells by suppressing the EGFR/PI3-K/AKT pathway.
  • [18F]ML-10 PET/CT demonstrated clear tumor uptake post-treatment, correlating strongly with apoptosis.
  • [18F]FDG uptake showed no trend and correlated with Glut-1, not treatment response.

Conclusions:

  • Cetuximab enhances radiosensitivity and apoptosis in NPC cells, both in vitro and in vivo.
  • [18F]ML-10 PET/CT is a promising imaging tool for predicting nasopharyngeal carcinoma treatment response.