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M Spriet1, P Espinosa-Mur1, D D Cissell1

  • 1School of Veterinary Medicine, University of California, Davis, California, USA.

Equine Veterinary Journal
|September 16, 2018
PubMed
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Positron emission tomography (PET) with 18 F-sodium fluoride (18F-NaF) effectively detects early bone changes in Thoroughbred racehorses, aiding in the prevention of catastrophic injuries. This advanced imaging method shows promise for identifying subtle lesions missed by other techniques.

Area of Science:

  • Veterinary diagnostic imaging
  • Equine orthopedics
  • Nuclear medicine

Background:

  • Early detection of stress remodelling in racehorses is crucial for preventing severe injuries.
  • Conventional imaging methods often fail to identify subtle, early changes.
  • 18F-NaF PET offers high sensitivity for detecting early bone turnover.

Purpose of the Study:

  • To validate 18F-NaF PET for clinical use in Thoroughbred racehorses.
  • To evaluate PET's ability to detect bone lesions.
  • To compare PET findings with other imaging modalities, clinical data, and pathology.

Main Methods:

  • Experimental exploratory study involving twenty Thoroughbred racehorse fetlocks.
  • Imaging modalities included 18F-NaF PET, CT, scintigraphy, MRI, and histology.
Keywords:
bonecomputed tomographyhorsemagnetic resonance imagingmetacarpophalangealscintigraphystress

Related Experiment Videos

  • Independent review by three board-certified radiologists and correlation of all findings.

    • Main Results:

    • 18F-NaF PET was well-tolerated and detected abnormalities missed by other imaging, particularly in proximal sesamoid bones.
    • Maximal standardized uptake values quantified lesion activity.
    • PET findings correlated with increased vascularity and osteoblastic activity.

    Conclusions:

    • 18F-NaF PET is a feasible and effective imaging modality for Thoroughbred fetlocks.
    • PET favorably compares with other methods for detecting stress remodelling.
    • PET may help prevent catastrophic musculoskeletal injuries through early detection of stress remodelling.