Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:05

Long-term Depression

33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Band Theory02:35

Band Theory

17.2K
When two or more atoms come together to form a molecule, their atomic orbitals combine and molecular orbitals of distinct energies result. In a solid, there are a large number of atoms, and therefore a large number of atomic orbitals that may be combined into molecular orbitals. These groups of molecular orbitals are so closely placed together to form continuous regions of energies, known as the bands.
The energy difference between these bands is known as the band gap.
Conductor, Semiconductor,...
17.2K
Scientific Laws and Theories02:31

Scientific Laws and Theories

88.7K
Scientific Laws
88.7K
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

40.2K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.2K
Attribution Theory00:56

Attribution Theory

13.8K
Behavior is a product of both the situation (e.g., cultural influences, social roles, and the presence of bystanders) and of the person (e.g., personality characteristics). Subfields of psychology tend to focus on one influence or behavior over others. Situationism is the view that our behavior and actions are determined by our immediate environment and surroundings. In contrast, dispositionism holds that our behavior is determined by internal factors (Heider, 1958).
13.8K
The Atomic Theory of Matter02:59

The Atomic Theory of Matter

128.2K
The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter was composed of small, finite particles that they called atomos, meaning “indivisible.” Later, Aristotle and others came to the conclusion that matter consisted of various combinations of the four “elements” — fire, earth, air, and water — and could be infinitely divided. Interestingly, these philosophers...
128.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nocturnal vagus nerve stimulation enhances cognitive functions in patients with early Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

CXCL12/CXCR4 axis as a modulator of neurotransmission in depression: A neuroimmune perspective.

Neuroscience and biobehavioral reviews·2026
Same author

Expert group recommendations on the use of antipsychotic drugs in patients with somatic diseases. Part I: (metabolic syndrome, cardiovascular diseases).

Psychiatria polska·2026
Same author

Expert group recommendations on the use of antipsychotic drugs in patients with somatic diseases. Part II: renal failure, liver failure, neurological diseases.

Psychiatria polska·2026
Same author

Genetics and Neurobiology of Treatment-Resistant Depression-A Review.

International journal of molecular sciences·2025
Same author

Bipolar disorder in children, adolescents, and young adults. Part 1. Clinical symptoms and differential diagnosis. Recommendations under the patronage of the Executive Board of the Polish Psychiatric Association, National Consultants in the field of Psychiatry and National Consultants in Child and Adolescent Psychiatry.

Psychiatria polska·2025

Related Experiment Video

Updated: Feb 5, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

39.9K

Inflammatory theory of depression.

Piotr Gałecki1, Monika Talarowska1

  • 1Klinika Psychiatrii Dorosłych, Uniwersytet Medyczny w Łodzi.

Psychiatria Polska
|September 16, 2018
PubMed
Summary

Inflammation and oxidative stress are increasingly linked to depression. These processes disrupt serotonin and melatonin levels, contributing to depressive disorders and significant societal costs.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • Brain diseases, particularly mental disorders like depression, impose substantial socioeconomic burdens in Europe.
  • Recurrent depressive disorders represent a significant modern health challenge.
  • Inflammation and oxidative stress are emerging as key factors in understanding depression's etiology.

Purpose of the Study:

  • To review recent studies on the role of inflammation and oxidative stress in the development of depression.
  • To explore the biological mechanisms linking inflammation to depressive symptoms.

Main Methods:

  • Review of current scientific literature on inflammation markers and depression.
  • Analysis of the kynurenine pathway's role in neurotransmitter deficits.
Keywords:
cognitiondepressionemotionsinflammation theory

More Related Videos

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

22.3K
On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.4K

Related Experiment Videos

Last Updated: Feb 5, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

39.9K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

22.3K
On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.4K
  • Examination of oxidative stress markers in relation to depressive disorders.

    • Main Results:

    • Inflammatory enzymes (e.g., MnSOD, MPO), cytokines, and oxidative stress are identified as crucial inflammation markers.
    • These inflammatory factors contribute to a deficit in serotonin and melatonin via the kynurenine pathway.
    • Depression can be conceptualized as a chronic response to stressors, involving systemic inflammation.

    Conclusions:

    • Inflammation and oxidative stress are critical biological processes implicated in the pathophysiology of depression.
    • Understanding these mechanisms offers new perspectives on depression as a complex, multifactorial disorder.
    • Further research into anti-inflammatory and antioxidant strategies may hold therapeutic potential for depressive disorders.