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Pan-HER-targeted approach for cancer therapy: Mechanisms, recent advances and clinical prospect

Manni Wang1, Yuzhu Hu1, Ting Yu1

  • 1Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan, 610041, PR China.

Cancer Letters
|September 16, 2018
PubMed

Insights

The Human Epidermal Growth Factor Receptor (HER) family is crucial in cancer. Combining HER-targeting therapies shows promise, but overcoming resistance requires novel strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The Human Epidermal Growth Factor Receptor (HER) family comprises four receptor tyrosine kinases implicated in various human cancers.
  • HER signaling pathways play a significant role in tumor initiation, progression, and metastasis.

Purpose of the Study:

  • To critically review the molecular mechanisms of HER receptor involvement in tumor progression.
  • To summarize recent advancements in anti-HER drug development based on clinical trial data.
  • To explore potential mechanisms of resistance to anti-HER therapies.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of data from clinical trials evaluating HER inhibitors.
  • Synthesis of information on molecular pathways and resistance mechanisms.

Main Results:

  • Multiple HER-targeting blockade demonstrates superior inhibitory effects compared to single receptor antagonists in clinical trials.
  • Significant patient resistance to current anti-HER therapies necessitates the development of novel treatment strategies.
  • Understanding resistance mechanisms is key to improving therapeutic outcomes.

Conclusions:

  • The HER family is a critical target in oncology, with combination therapies showing enhanced efficacy.
  • Overcoming therapeutic resistance in anti-HER therapy is a major challenge requiring further research.
  • Future strategies should focus on novel drug development and combination approaches to address resistance.
Keywords:
CancerPan-HERTarget therapy

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