Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Pilot Study of the EMPOWER Music-based Intervention to Reduce Pulmonary Air Trapping in COPD.

medRxiv : the preprint server for health sciences·2026
Same author

Integrated multi-omic profiling reveals two distinct splenic marginal zone lymphoma subgroups with prognostic relevance.

Blood advances·2026
Same author

An epigenetic Achilles' heel in extranodal NK/T-cell lymphoma?

Haematologica·2026
Same author

Rosemary leaves extract mediated green synthesis of silver functionalized BiFeO<sub>3</sub> nanoparticles with improved visible light photocatalytic performance.

Discover nano·2026
Same author

Assessing uncertainty in forensic alcohol calculations: The case for using percentile ranges.

Journal of forensic sciences·2026
Same author

Statistics is important in medical misconduct cases.

BMJ (Clinical research ed.)·2026
Same journal

Intrapulmonary solitary fibrous tumor: clinicopathological analysis of 29 cases with emphasis on morphological spectrum and immunohistochemical profile.

Diagnostic pathology·2026
Same journal

Evaluation of squamous cell carcinoma antigen as a diagnostic biomarker in pulmonary diseases: a male cohort study.

Diagnostic pathology·2026
Same journal

Biosensors for oral cancer detection: a scoping review.

Diagnostic pathology·2026
Same journal

Clinicopathological characteristics across the HER2 expression spectrum in invasive breast carcinoma of no special type: a single-centre retrospective study.

Diagnostic pathology·2026
Same journal

Rapid slide-level assessment of glomerular yield using virtual staining of unstained renal biopsy sections.

Diagnostic pathology·2026
Same journal

Expression differences and clinical significance of PD-L1 in lung cancer patients with different histological types and differentiation degrees.

Diagnostic pathology·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy OCM
10:13

Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy OCM

Published on: December 12, 2016

11.6K

PD1

Katherine Wickenden1, Nadia Nawaz1, Sami Mamand1

  • 1Leicester Cancer Research Centre and Ernest and Helen Scott Haematology Research Institute, University of Leicester, Lancaster Road, Leicester, LE1 7HB, UK.

Diagnostic Pathology
|September 17, 2018
PubMed
Summary
This summary is machine-generated.

Follicular helper (Tfh) cells drive marginal zone lymphoma B-cell proliferation. This study reveals complex T-cell infiltration patterns and their association with lymphoma cells using advanced imaging.

Keywords:
Follicular helper T-cellsMarginal zone lymphomaSpatial characteristics

More Related Videos

High-Throughput Automated Multiplex Immunofluorescence Assays for Translational Research
09:12

High-Throughput Automated Multiplex Immunofluorescence Assays for Translational Research

Published on: June 10, 2025

1.1K
In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
08:04

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Published on: February 27, 2019

12.5K

Related Experiment Videos

Last Updated: Feb 5, 2026

Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy OCM
10:13

Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy OCM

Published on: December 12, 2016

11.6K
High-Throughput Automated Multiplex Immunofluorescence Assays for Translational Research
09:12

High-Throughput Automated Multiplex Immunofluorescence Assays for Translational Research

Published on: June 10, 2025

1.1K
In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
08:04

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Published on: February 27, 2019

12.5K

Area of Science:

  • Immunology
  • Oncology
  • Pathology

Background:

  • Marginal zone lymphoma (MZL) involves sustained immune reactions driving B-cell proliferation.
  • The role and spatial distribution of CD4+ T-cell subsets in the MZL tumor microenvironment are poorly understood.

Purpose of the Study:

  • To characterize CD4+ T-cell subsets within the MZL tumor microenvironment.
  • To investigate the spatial distribution and association of T-cells with proliferating lymphoma B-cells.

Main Methods:

  • Multiplex semi-automated immunohistochemistry combined with image processing.
  • Analysis of follicular helper (Tfh) cells (PD1hi) and regulatory (Treg) T-cells (FOXP3+).
  • Statistical analysis including Pearson correlation and Morisita-Horn index for cell interactions.

Main Results:

  • Significant variation in Tfh and Treg cell numbers and Tfh:Treg ratio among MZL cases.
  • PD1hi cells exhibited significantly more clustering than FOXP3+ cells.
  • PD1hi cells were found to be associated with proliferating B-cells.

Conclusions:

  • The study reveals unexpected architectural complexity of T-cell infiltration in MZL.
  • Findings support a key role for Tfh cells in driving lymphoma B-cell proliferation.
  • Digital analysis of T-cell spatial architecture in MZL is feasible, with potential clinical implications.