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Correlations of Circulating Cell-Free DNA With Clinical Manifestations in Acute Myocardial Infarction

Jin Xie1, Jiawei Yang1, Pei Hu1

  • 1Department of Cardiology, Jingzhou Central Hospital, the Second Clinical Medical College, Yangtze University, Jingzhou, Hubei Sheng, China.

The American Journal of the Medical Sciences
|September 17, 2018
PubMed

Insights

Circulating cell free DNA (cfDNA) levels are significantly elevated in acute myocardial infarction (AMI) patients, correlating with disease severity. Monitoring cfDNA shows potential for identifying high-risk cardiovascular disease individuals.

Area of Science:

  • Biomarkers
  • Cardiovascular Disease Research
  • Molecular Diagnostics

Background:

  • Acute myocardial infarction (AMI) is a critical cardiovascular disease (CVD).
  • Circulating cell free DNA (cfDNA) is increasingly studied as a potential biomarker.
  • The clinical utility of cfDNA in AMI requires further investigation.

Purpose of the Study:

  • To evaluate the role of cfDNA in patients with AMI.
  • To correlate cfDNA levels with clinical features and disease status in CVD patients.
  • To assess the value of serial cfDNA monitoring for disease progression and complications.

Main Methods:

  • Quantification of cfDNA using PicoGreen dsDNA assay.
  • Serial blood sampling from 130 CVD patients (100 with AMI) and 30 healthy volunteers.
  • Short-term and medium-term monitoring of cfDNA concentrations.

Main Results:

  • Mean cfDNA concentration was 5-fold higher in AMI patients compared to healthy volunteers.
  • cfDNA levels were elevated in AMI patients and higher than in other CVD patients.
  • Short-term monitoring revealed trends linked to disease severity and complications.
  • Medium-term monitoring identified two groups: those with normalized cfDNA and those with persistently high levels.

Conclusions:

  • cfDNA measurement in CVD patients offers a novel monitoring approach.
  • cfDNA has potential clinical applications for identifying high-risk individuals.
  • Serial cfDNA monitoring may provide insights into disease trajectory and prognosis.
Abstract

Keywords:
Acute myocardial infarctionBiomarkersCardiovascular diseaseCell free DNASerial monitoring

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