Interstitial lung disease: Elementary lesions and diagnosis

Area of Science:

• Pulmonology
• Pathology
• Histology

Background:

• Interstitial lung diseases (ILDs) present a diagnostic challenge.
• A standardized evaluation method is crucial for accurate ILD diagnosis.

Purpose of the Study:

• To present a structured approach to ILD diagnosis.
• To outline key histologic patterns for ILD evaluation.

Main Methods:

• Utilizing scanning microscopy for initial assessment.
• Employing a structured analysis based on defined histologic patterns.
• Illustrating various histologic patterns and associated disease entities.

Main Results:

• Histologic patterns identified include: acute injury, fibrosis, cellular infiltrates, airspace filling, nodule formation, and minimal changes.
• The study provides illustrations for each pattern.
• Discussion links patterns to specific ILD entities.

Conclusions:

• A standardized, pattern-based histologic evaluation enhances ILD diagnosis.
• Leslie's defined patterns offer a systematic framework for assessment.
• This approach aids in differentiating various interstitial lung diseases.