Related Experiment Video
Updated: Feb 5, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
Severe Obesity in Children May Not Pose Independent Risk for Influenza Complications
Vickie L Neyer1, Jessica G Woo2, Robert M Siegel2
1Cincinnati Children's Hospital Medical Center, USA; Indiana Wesleyan University, USA.
Insights
Severe obesity in children does not independently increase influenza complication risk requiring hospitalization. Therefore, vaccination targeting should not be based solely on weight status in pediatric patients.
Area of Science:
- Pediatric Health
- Infectious Diseases
- Public Health
Background:
- Influenza vaccination targets children with conditions increasing complication risk.
- Severe obesity is defined as body mass index (BMI) ≥99% for age and gender.
- Influenza complications include hospitalization or death.
Purpose of the Study:
- To determine if severe obesity in children is an independent risk factor for influenza complications.
- To inform vaccination strategies for pediatric populations.
Main Methods:
- Retrospective chart review of 188 pediatric influenza complication cases (2 to <20 years old).
- Cases were analyzed for severe obesity (BMI ≥99%) and pre-existing high-risk conditions.
- Statistical analysis compared severe obesity status with influenza complications.
Main Results:
- 93% of cases had a known high-risk condition; only 7% had no known condition.
- All patients with severe obesity (BMI ≥99%) had a known high-risk condition.
- Severe obesity was not a statistically significant independent risk factor for influenza complications (p=0.61).
Conclusions:
- Severe obesity alone is not an independent high-risk condition for severe influenza complications in children.
- Clinicians should not target children for influenza vaccination based solely on weight status.
- Further research is needed on severe obesity and less severe influenza cases.
Purpose:
Subsets of children are targeted for influenza vaccination due to known conditions that increase the risk of influenza complications. The purpose of this study was to determine if severe obesity in children suggests targeted vaccination.
Design And Methods:
A retrospective chart review of a large Midwestern pediatric hospital identified 188 cases of influenza complications (defined as requiring hospitalization or death) aged 2 to <20 years old from August 1, 2010 through June 30, 2013. Severe obesity was defined as body mass index (BMI) ≥99% for age and gender, with patients grouped by severe obesity status (yes vs. no). Cases were reviewed for previously identified risk conditions for influenza complications (e.g., asthma, pneumonia, diabetes), and were classified as having or not having a known high risk condition.
Results:
Of 188 cases, 174 (93%) had a high-risk condition, while only 14 (7%) had no known condition. All 14 (100%) with no known high-risk condition had a BMI <99%. All 15 (100%) with BMI ≥99% had a known high-risk condition. The association between severe obesity status and influenza complications was not statistically significant (p = 0.61).
Conclusions:
This suggests that severe obesity in children is not an independent high-risk condition for influenza complications defined as requiring hospitalization or resulting in death, once other known influenza risk factors are considered.
Implications:
Based on this data, clinicians should not target children for influenza vaccination based on weight status. We cannot comment about whether severe obesity represents increased risk for less severe cases of influenza.
Related Concept Videos
Obesity
Introduction to Test of Independence
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
Hypothesis Test for Test of Independence
H0: The two variables (factors)...
Law of Independent Assortment
Hemodialysis II: Procedure and Complications
Relative Risk

