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Updated: Feb 5, 2026
05:59
Visualization of Intensity Levels to Reduce the Gap Between Self-Reported and Directly Measured Physical Activity
Published on: March 7, 2019
7.3K
Physical Activity and Cognitive Function among Older Adults with an Elevated Gamma Gap.
Emily Frith1, Paul D Loprinzi2
1Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, The University of Mississipi, University, Mississippi, USA.
Summary
An elevated gamma gap in older adults is linked to lower cognitive function. However, regular physical activity may help preserve cognitive function in those with an elevated gamma gap.
Area of Science:
- Gerontology
- Neuroscience
- Biochemistry
Background:
- Inflammation, indicated by an elevated gamma gap, is linked to cognitive decline.
- Physical activity has known anti-inflammatory and cognitive benefits.
Purpose of the Study:
- To investigate the association between the gamma gap and cognitive function in older adults.
- To determine if physical activity favorably influences cognitive function in older adults with an elevated gamma gap.
Main Methods:
- Utilized data from 2,352 older adults (aged 60-85) from the National Health and Nutrition Examination Survey (NHANES).
- Calculated the gamma gap by subtracting albumin from total protein; an elevated gamma gap was defined as ≥3.1 g/dL.
- Assessed cognitive function using the Digit Symbol Substitution Test (DSST) and collected data on physical activity levels.
Main Results:
- Older adults with an elevated gamma gap exhibited significantly lower cognitive function scores (DSST, 44.8) compared to those without (DSST, 50.1).
- Among individuals with an elevated gamma gap, meeting moderate-to-vigorous physical activity (MVPA) guidelines was associated with a 6.42-unit higher DSST score.
Conclusions:
- The gamma gap is associated with cognitive function in older adults.
- Physical activity is linked to better cognitive function, particularly in older adults with an elevated gamma gap.
- Further research is warranted to explore physical activity interventions for managing elevated gamma gap and cognitive health.
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