Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.4K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.4K
Common Ion Effect03:24

Common Ion Effect

46.8K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
46.8K
Gastric Motility01:16

Gastric Motility

3.2K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
3.2K
Gastric Emptying01:16

Gastric Emptying

3.8K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
3.8K
Variability: Analysis01:11

Variability: Analysis

519
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
519
Random Variables01:09

Random Variables

17.9K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact on airborne isolation duration utilizing GeneXpert versus acid-fast bacilli smears to guide discontinuation among individuals with suspected pulmonary tuberculosis: a systematic review and meta-analysis.

Infection control and hospital epidemiology·2026
Same author

Machine learning reveals X chromosome transcriptional signatures that classify systemic lupus erythematosus in females.

BMC rheumatology·2026
Same author

Sustained clinical remission and relapse of severe eosinophilic asthma following long-term mepolizumab treatment.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same author

Australasian Society of Clinical Immunology and Allergy consensus statement on IEI molecular diagnosis.

Journal of human immunity·2026
Same author

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase.

Proteins·2026
Same author

A Real-World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026

Related Experiment Video

Updated: Feb 5, 2026

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
08:42

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Published on: July 19, 2019

10.7K

Gastric Cancer Screening in Common Variable Immunodeficiency.

David K van der Poorten1,2, Duncan McLeod3,4, Golo Ahlenstiel2,5,6,7

  • 1Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney, NSW, Australia.

Journal of Clinical Immunology
|September 17, 2018
PubMed
Summary

Patients with common variable immunodeficiency (CVID) have a high prevalence of premalignant gastric lesions, increasing their risk for gastric cancer and lymphoma. Routine gastric screening is recommended for CVID patients to detect these conditions early.

Keywords:
CVIDCommon variable immunodeficiencygastric cancergastroscopyintestinal metaplasia

More Related Videos

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

7.4K
Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells
09:24

Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells

Published on: May 9, 2020

4.8K

Related Experiment Videos

Last Updated: Feb 5, 2026

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
08:42

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Published on: July 19, 2019

10.7K
Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

7.4K
Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells
09:24

Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells

Published on: May 9, 2020

4.8K

Area of Science:

  • Gastroenterology
  • Immunology
  • Oncology

Background:

  • Common variable immunodeficiency (CVID) patients face elevated risks of gastric cancer and gastrointestinal lymphoma.
  • Routine screening for premalignant gastric lesions is not standard practice for CVID patients.
  • Existing screening protocols lack universal applicability to the CVID population.

Purpose of the Study:

  • To investigate the prevalence of premalignant gastric lesions in CVID patients.
  • To compare gastric pathology in CVID patients versus a control group.
  • To propose an improved gastric screening protocol for CVID patients.

Main Methods:

  • Fifty-two CVID patients underwent screening gastroscopy, compared with 40 controls.
  • Histopathological analysis of gastric biopsies was performed.
  • Risk factors for high-risk gastric pathology were assessed.

Main Results:

  • 34% of CVID patients exhibited premalignant lesions (intestinal metaplasia, atrophic gastritis) versus 7.5% of controls (p < 0.01).
  • Focal nodular lymphoid hyperplasia, a precursor to gastrointestinal lymphoma, was found in 16% of CVID patients.
  • High-risk pathology correlated with disease duration, smoking, H. pylori, low pepsinogen I, and diarrhea.

Conclusions:

  • Premalignant gastric lesions are highly prevalent in CVID patients, necessitating routine screening.
  • Standardized biopsy protocols are crucial for accurate detection of lesions.
  • A novel screening protocol is proposed to mitigate gastric cancer and lymphoma risks in CVID.