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Decrease in the expression level of the gene encoding the putative Bombyx mori bidensovirus receptor during virus

Katsuhiko Ito1, Takeshi Fujii2, Takeshi Yokoyama2

  • 1Department of Science of Biological Production, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 183-8509, Japan. katsuito@cc.tuat.ac.jp.

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Bombyx mori bidensovirus (BmBDV) infection significantly decreases the expression of the susceptibility gene +nsd-2 in silkworms. This suggests BmBDV infection impacts transporter gene expression in the silkworm midgut.

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Area of Science:

  • Insect Pathology
  • Molecular Biology
  • Genetics

Background:

  • Bombyx mori bidensovirus (BmBDV) causes fatal disease in silkworms by replicating in midgut columnar cells.
  • Resistance to BmBDV is controlled by the nsd-2 gene, which encodes a putative amino acid transporter potentially acting as a viral receptor.

Purpose of the Study:

  • To investigate the relationship between BmBDV and its putative receptor, nsd-2.
  • To analyze the expression pattern of the susceptibility allele +nsd-2 following BmBDV infection.

Main Methods:

  • Quantitative RT-PCR was used to analyze gene expression.
  • Total RNA was isolated from the midguts of both uninfected and BmBDV-infected silkworms.
  • Expression levels of +nsd-2 and 26 other midgut transporter genes were compared.

Main Results:

  • The expression of +nsd-2 showed no change in uninfected silkworms but drastically decreased in BmBDV-infected silkworms.
  • A negative correlation was observed between viral transcript levels and +nsd-2 expression.
  • Expression of three additional transporter genes also decreased post-infection, mirroring the trend of +nsd-2.

Conclusions:

  • BmBDV infection negatively impacts the expression of the +nsd-2 gene in silkworms.
  • The findings suggest that BmBDV infection affects the expression of multiple transporter genes in the silkworm midgut, including the putative viral receptor +nsd-2.