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Continuous Subcutaneous Insulin Infusion Characteristics in Type 1 Diabetes Children and Adolescents in Qatar

Goran Petrovski1, Fawziya Al Khalaf2, Khalid Hussain2

  • 1Pediatrics, Endocrine and Diabetes Division, Sidra Medicine, Doha, Qatar. gpetrovski@sidra.org.

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
|September 17, 2018
PubMed

Insights

Continuous subcutaneous insulin infusion (CSII) significantly improved glucose control in children and adolescents with type 1 diabetes mellitus (T1DM) in Qatar. This study demonstrated a notable reduction in HbA1c levels after one year of CSII use.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Diabetes Technology

Background:

  • Type 1 diabetes mellitus (T1DM) requires intensive management to prevent complications.
  • Continuous subcutaneous insulin infusion (CSII) offers a flexible alternative to multiple daily injections.
  • Standardized protocols are crucial for optimizing CSII outcomes in pediatric populations.

Purpose of the Study:

  • To evaluate the effectiveness of CSII in improving glycemic control in children and adolescents with T1DM.
  • To describe CSII usage characteristics in a Qatari cohort.
  • To assess the impact of a standardized CSII protocol on HbA1c levels.

Main Methods:

  • A cohort of 138 T1DM patients (mean age 9.8 years) initiated CSII using Medtronic insulin pumps.
  • CSII characteristics and glycated hemoglobin (HbA1c) were assessed one year post-initiation.
  • Data analysis focused on changes in insulin dosage and HbA1c levels.

Main Results:

  • A significant increase in daily insulin dose (0.59 to 0.74 U/kg/24h) was observed.
  • Glycated hemoglobin (HbA1c) levels significantly decreased from 9.7% to 8.1% (P < 0.05).
  • Over 92% of patients utilized the Bolus Wizard feature with specific settings for insulin-to-carbohydrate ratio, insulin sensitivity, and target glucose ranges.

Conclusions:

  • CSII, when implemented with a standardized protocol, significantly enhances glucose control in pediatric T1DM patients.
  • A mean HbA1c reduction of 1.6% was achieved within one year of CSII initiation.
  • Longer-term studies are warranted to confirm these findings and assess sustained benefits.
Abstract

Keywords:
CSIIGlucose controlType 1 diabetes

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