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Updated: Feb 5, 2026

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
Published on: January 6, 2023
Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia
Rolla F Abu-Arja1,2, Jamie L Dargart3, Rajinder P S Bajwa1,2
1Department of Pediatric Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio.
This case study highlights a rare instance of identical twins diagnosed with RAM acute myeloid leukemia (AML). Achieving minimal residual disease (MRD) negativity before a stem cell transplant is crucial for favorable outcomes in high-risk AML.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Acute myeloid leukemia (AML) with the RAM immunophenotype presents a significant challenge due to its extremely poor prognosis.
- Monozygotic twins diagnosed simultaneously with RAM AML are exceptionally rare, offering a unique opportunity to study disease progression and treatment responses.
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