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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
An alternative stereoselective total synthesis of (-)-pyrenophorol
Gurrala Alluraiah1, Reddymasu Sreenivasulu2, Choragudi Chandrasekhar2
1a Department of Chemistry, Acharya Nagarjuna University , Nagarjuna Nagar , A.P , India.
Abstract:
The total synthesis of 16-membered C2-Symmetric dilactone (-)-Pyrenophorol was accomplished starting from commercially available (S)-epoxide prepared by hydrolytic kinetic resolution of (±) - epoxide with key steps of Grignard reaction, Swern oxidation, Wittig reaction and cyclization was achieved by intermolecular Mitsunobu cyclization. The synthesis of (-)-Pyrenophorol accomplished from cheaply available starting material, easily work-up procedures and reduction of cost in industrial process were major advantages of this route.
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