Related Experiment Video
Updated: Feb 5, 2026
04:46
Isolation of Lymphocytes from Mouse Genital Tract Mucosa
Published on: September 3, 2012
14.9K
Can pharmacotherapy help persistent genital arousal disorder?
1a Department of Psychiatry, Social Psychiatry and Psychotherapy, Division of Clinical Psychology and Sexual Medicine , Hannover Medical School , Hannover , Germany.
Expert Opinion on Pharmacotherapy
|September 18, 2018
Summary
Persistent genital arousal disorder (PGAD) is a poorly understood condition. Current treatments are limited, with some medications potentially worsening symptoms, highlighting the need for more research.
Area of Science:
- Gynecology
- Pharmacology
- Sexual Medicine
Background:
- Persistent genital arousal disorder (PGAD) is a rare but debilitating condition.
- It is not yet recognized in international disease classifications.
- Affected patients experience significant suffering.
Purpose of the Study:
- To provide an overview of existing studies and case reports on PGAD.
- To offer expert opinion on treatment and pharmacotherapy for PGAD.
- To guide clinicians in managing patients with PGAD.
Main Methods:
- Review of case reports, case series, and surveys on medications related to PGAD.
- Analysis of drugs that alleviate or exacerbate PGAD symptoms.
Main Results:
- Pharmacological treatment data for PGAD is scarce, primarily based on case reports.
- Serotonin reuptake inhibitors (SSRIs) may induce or worsen PGAD.
- Drugs like pregabalin or duloxetine may be considered for symptom management.
Conclusions:
- Further research into the etiology and clinical trials for PGAD treatments are urgently needed.
- Clinicians should prioritize careful diagnostics and patient counseling.
- Consideration of medications that inhibit sexual excitation or modulate sensory perception may be beneficial.
Related Concept Videos
01:26Psychosis: Goals of Pharmacotherapy
539
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
539
01:15Diabetes: Management and Pharmacotherapy
1.1K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
01:23Optimal Arousal Theory
856
The optimal arousal theory suggests that performance is maximized when an individual experiences a moderate level of arousal. This theory is closely tied to the Yerkes-Dodson law, which illustrates an inverted U-shaped relationship between arousal and performance. The law, formulated by psychologists Robert Yerkes and John Dodson, implies an ideal arousal level for optimal performance, and deviations from this level can lead to declines in effectiveness.
Inverted U-Shaped Performance Curve
The...
Inverted U-Shaped Performance Curve
The...
856
01:15External Female Genitals
33.8K
The vulva encompasses the external structures of the female reproductive system. At the forefront is the monpubis, a cushion of fatty tissue atop the pubic bone. Once puberty sets in, this area typically grows hair. Extending from just behind the mons pubis are the labia majora (labia = 'lips'; majora = 'larger'), which are larger skin fs olds coated with hair. Nestled within are the labia minora (labia = 'lips'; minora = 'smaller'), which are thinner, more...
33.8K
01:23Psychosexual Stages of Personality: Genital
1.8K
The genital stage is the final phase of Sigmund Freud's theory of psychosexual development, beginning at puberty, around age 12. During this stage, sexual energy shifts from self-focused interests to external individuals, marking the development of mature adult sexuality. Freud saw this phase as a time of sexual reawakening, with desires directed toward others outside the family. A healthy transition into this stage, according to Freud, signifies the emergence of two key aspects of adult...
1.8K
02:18Intrinsically Disordered Proteins
19.5K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.5K