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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Primary and Secondary Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction
Marco Giuseppe Del Buono1, Leo Buckley2, Antonio Abbate3
1VCU Pauley Heart Center, Wright Center for Clinical and Translational Research, Richmond, Virginia; Department of Cardiovascular Medicine, Catholic University, Rome, Italy.
The American Journal of Cardiology
|September 18, 2018
Summary
Heart failure with preserved ejection fraction (HFpEF) affects many patients. Differentiating primary HFpEF from secondary HFpEF is crucial for understanding prognosis and hospitalization risks.
Area of Science:
- Cardiology
- Internal Medicine
- Heart Failure Research
Background:
- Heart failure with preserved ejection fraction (HFpEF) accounts for about 50% of heart failure cases.
- HFpEF is characterized by preserved left ventricular ejection fraction (LVEF) ≥50%.
- Distinguishing between primary and secondary causes of HFpEF is clinically significant.
Purpose of the Study:
- To review the diagnostic approach for HFpEF.
- To present a differential diagnosis distinguishing primary from secondary HFpEF.
Main Methods:
- Literature review of diagnostic strategies for HFpEF.
- Analysis of clinical characteristics differentiating primary and secondary HFpEF.
Main Results:
- Primary HFpEF patients have lower cardiovascular mortality than HFrEF and secondary HFpEF.
- Primary HFpEF patients face a significantly higher risk of HF hospitalization compared to individuals without HFpEF.
Conclusions:
- Accurate diagnosis and differentiation of HFpEF subtypes are essential.
- Understanding the distinction between primary and secondary HFpEF impacts patient management and risk stratification.
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