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Clinical infrared microscopic imaging: An overview.

J D Pallua1, A Brunner2, B Zelger2

  • 1Department of Pathology, Medical University of Innsbruck, Müllerstraße 44, 6020, Innsbruck, Austria; Institute of Legal Medicine, Medical University of Innsbruck, Müllerstraße 44, 6020, Innsbruck, Austria.

Pathology, Research and Practice
|September 18, 2018
PubMed
Summary

Mid-infrared microscopic imaging provides cellular-level molecular analysis for tissues. This technique offers chemo-morphological insights crucial for interpreting pathological changes in clinical research.

Keywords:
Chemical as well as physical sample propertiesHistopathologyMid-infrared microscopic imagingMolecular fingerprintStatistical classificationThree-dimensional image data cube

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Area of Science:

  • Biomedical Imaging
  • Spectroscopy
  • Pathology

Background:

  • Mid-infrared (MIR) microscopic imaging has advanced significantly, becoming a standard technique.
  • This method provides global sample analysis with near-cellular resolution.
  • It enables the acquisition of local molecular expression profiles within samples.

Purpose of the Study:

  • To review the advancements in Mid-infrared microscopic imaging instrumentation and data analysis.
  • To highlight the capabilities of MIR imaging in providing chemo-morphological tissue information.
  • To discuss the applications of MIR microscopic imaging in clinical research.

Main Methods:

  • Overview of MIR microscopic imaging instrumentation.
  • Discussion of MIR data analysis techniques.
  • Review of case studies and applications in clinical settings.

Main Results:

  • MIR imaging offers a powerful tool for detailed tissue analysis.
  • Chemo-morphological data aids in understanding tissue status.
  • The technique's resolution is suitable for cellular-level investigations.

Conclusions:

  • Mid-infrared microscopic imaging is a conventional and valuable technique in clinical research.
  • Its ability to provide molecular and morphological data is essential for pathology.
  • Further applications in clinical diagnostics and research are anticipated.