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Related Concept Videos

Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

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It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
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Structures of Solids02:22

Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Structural Isomerism02:34

Structural Isomerism

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Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
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Chromosome Structure02:40

Chromosome Structure

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A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
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Structure of Lipids03:38

Structure of Lipids

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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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Viral Structure00:56

Viral Structure

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Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
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Related Experiment Video

Updated: Feb 5, 2026

Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes
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Structures of the Human PGD

Lei Wang1, Dandan Yao2, R N V Krishna Deepak3

  • 1Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Molecular Cell
|September 18, 2018
PubMed
Summary
This summary is machine-generated.

Blocking CRTH2 signaling, a key pathway in type 2 inflammation, shows therapeutic potential. Crystal structures reveal how CRTH2 antagonists like fevipiprant bind, offering insights into novel lipid recognition mechanisms by G-protein-coupled receptors.

Keywords:
CRTH2GPCRasthmafevipiprantligand bindinglipidsprostaglandin D2structure

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High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

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Area of Science:

  • Structural Biology
  • Immunology
  • Pharmacology

Background:

  • Prostaglandin D2 (PGD2) signaling via CRTH2 receptor is central to type 2 inflammation.
  • CRTH2 antagonists are investigated for treating inflammatory disorders, with fevipiprant in phase 3 trials for asthma.

Purpose of the Study:

  • To elucidate the structural basis of CRTH2 antagonist binding.
  • To understand the mechanism of CRTH2 activation and ligand recognition.

Main Methods:

  • X-ray crystallography of human CRTH2 with fevipiprant and CAY10471.
  • Molecular docking and ligand-binding assays.

Main Results:

  • Crystal structures reveal a semi-occluded binding pocket influenced by the CRTH2 amino terminus.
  • Diverse CRTH2 antagonists exhibit distinct binding modes.
  • Structural data suggest a specific ligand entry port and binding mechanism for PGD2, differing from other lipids.

Conclusions:

  • The findings provide atomic-level insights into CRTH2 antagonist binding and function.
  • A novel mechanism for G-protein-coupled receptor lipid recognition is proposed.
  • Structural understanding may guide the development of more effective CRTH2-targeted therapies.