Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

280.7K
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
280.7K
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

10.8K
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
10.8K
Positive Regulator Molecules01:45

Positive Regulator Molecules

136.4K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
136.4K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.3K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.3K
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

70.4K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
70.4K
5-Number Summary01:04

5-Number Summary

5.7K
In a dataset, the 5-number summary includes the minimum data value, the data value of the first quartile, the median data value or data value of the second quartile, the data value of the third quartile, and the maximum data value. These 5 data values can be visualized as a box and whisker plot.
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration.

PLoS pathogens·2026
Same author

Human dynein-dynactin is a fast processive motor in living cells.

eLife·2026
Same author

The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration.

bioRxiv : the preprint server for biology·2025
Same author

Human dynein-dynactin is a fast processive motor in living cells.

bioRxiv : the preprint server for biology·2023
Same author

Improved survival of SARS COV-2-infected K18-<i>hACE2</i> mice treated with adenosine A<sub>2A</sub>R agonist.

Heliyon·2023
Same author

Regadenoson for the treatment of COVID-19: A five case clinical series and mouse studies.

PloS one·2023

Related Experiment Video

Updated: Feb 5, 2026

Generating a "Humanized" Drosophila S2 Cell Line Sensitive to Pharmacological Inhibition of Kinesin-5
11:09

Generating a "Humanized" Drosophila S2 Cell Line Sensitive to Pharmacological Inhibition of Kinesin-5

Published on: January 20, 2016

7.8K

Kinesin-5 Regulation and Function in Mitosis.

Barbara J Mann1, Patricia Wadsworth1

  • 1Department of Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, USA.

Trends in Cell Biology
|September 18, 2018
PubMed
Summary
This summary is machine-generated.

Kinesin-5 motor proteins are crucial for forming and maintaining the bipolar mitotic spindle, essential for cell division. New research reveals how accessory proteins and modifications regulate these motors

Keywords:
Eg5kinesin-5mitosismitotic spindle

More Related Videos

Motility of Single Molecules and Clusters of Bi-Directional Kinesin-5 Cin8 Purified from S. cerevisiae Cells
10:46

Motility of Single Molecules and Clusters of Bi-Directional Kinesin-5 Cin8 Purified from S. cerevisiae Cells

Published on: February 2, 2022

3.0K
Isolation and Purification of Kinesin from Drosophila Embryos
09:49

Isolation and Purification of Kinesin from Drosophila Embryos

Published on: April 27, 2012

12.6K

Related Experiment Videos

Last Updated: Feb 5, 2026

Generating a "Humanized" Drosophila S2 Cell Line Sensitive to Pharmacological Inhibition of Kinesin-5
11:09

Generating a "Humanized" Drosophila S2 Cell Line Sensitive to Pharmacological Inhibition of Kinesin-5

Published on: January 20, 2016

7.8K
Motility of Single Molecules and Clusters of Bi-Directional Kinesin-5 Cin8 Purified from S. cerevisiae Cells
10:46

Motility of Single Molecules and Clusters of Bi-Directional Kinesin-5 Cin8 Purified from S. cerevisiae Cells

Published on: February 2, 2022

3.0K
Isolation and Purification of Kinesin from Drosophila Embryos
09:49

Isolation and Purification of Kinesin from Drosophila Embryos

Published on: April 27, 2012

12.6K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Chromosome segregation relies on a bipolar mitotic spindle for accurate cell division.
  • Kinesin-5 motor proteins are vital for establishing and maintaining spindle bipolarity and elongation.
  • Understanding spindle formation is fundamental for all eukaryotic cells.

Purpose of the Study:

  • To explore the fundamental importance of spindle formation, maintenance, and function in eukaryotic cells.
  • To investigate the role of kinesin-5 motor proteins in mitotic spindle organization.
  • To understand how accessory proteins and post-translational modifications regulate kinesin-5 motors.

Main Methods:

  • Review of recent research on kinesin-5 motor proteins.
  • Analysis of accessory proteins and post-translational modifications.
  • Examination of kinesin-5 motor movement along microtubules.

Main Results:

  • Kinesin-5 motors are essential for generating forces that establish and maintain spindle bipolarity.
  • Accessory proteins and post-translational modifications modulate kinesin-5 localization and activity.
  • Some kinesin-5 motors exhibit bidirectional movement along microtubules.

Conclusions:

  • Kinesin-5 motor proteins are key regulators of mitotic spindle architecture.
  • Post-translational modifications and accessory proteins offer novel regulatory mechanisms for kinesin-5 function.
  • Further research into kinesin-5 dynamics provides insights into cell division processes.