Related Experiment Video
Updated: Feb 5, 2026
05:12
A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
1.5K
Remote ischemic conditioning: a treatment for vascular cognitive impairment
David C Hess1, Mohammad B Khan1, Nasrul Hoda2
1Department of Neurology Medical College of Georgia, Georgia Regent's University, Augusta, GA USA.
Brain Circulation
|September 18, 2018
Summary
Remote ischemic conditioning (RIC) may treat white matter (WM) damage and vascular cognitive impairment (VCI). This "exercise equivalent" therapy could potentially slow disease progression, offering hope for patients with VCI and Alzheimer's disease (AD).
Area of Science:
- Neurology
- Cardiovascular Research
- Gerontology
Background:
- Vascular cognitive impairment (VCI) and leukoaraiosis are linked to white matter (WM) damage due to hypoperfusion.
- Current treatments focus on vascular risk factors, lacking specific therapies to halt disease progression towards dementia.
- Exercise shows potential in slowing Alzheimer's disease (AD) and VCI, but adherence is a challenge in older, disabled populations.
Purpose of the Study:
- To explore remote ischemic conditioning (RIC) as a potential therapeutic intervention for WM damage and VCI.
- To investigate RIC's capacity to increase cerebral blood flow (CBF) and mitigate neurodegenerative processes.
- To assess RIC's potential as an alternative to physical exercise for managing VCI and potentially AD.
Main Methods:
- Utilizing MRI imaging to monitor white matter (WM) progression in subjects.
- Implementing remote ischemic conditioning (RIC) as a home-based, device-administered therapy.
- Designing a study with approximately 100 subjects per group to evaluate RIC's efficacy.
Main Results:
- Pre-clinical and human studies indicate RIC increases cerebral blood flow (CBF).
- RIC is proposed as a viable therapeutic strategy for VCI and WM disease.
- The study design aims to determine RIC's activity in WM disease and VCI.
Conclusions:
- Remote ischemic conditioning (RIC) presents a promising, accessible therapy for white matter (WM) disease and vascular cognitive impairment (VCI).
- RIC's ability to increase CBF suggests potential benefits for neurodegenerative conditions like VCI and sporadic Alzheimer's disease (AD).
- Further research with adequate sample size is warranted to confirm RIC's therapeutic effects on WM disease and VCI progression.
Related Concept Videos
01:38Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
03:24Seedless Vascular Plants
67.0K
Seedless Vascular Plants Were the First Tall Plants on Earth
67.0K
01:27Language and Cognition
801
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
801
01:25Cognitive Therapy
1.0K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.0K
01:23Cognition and Behavior
376
Social psychology examines the complex interplay between individual mental processes and social interactions. Historically, the field was divided into two domains: social behavior and social cognition. Researchers focusing on social behavior analyzed actions within social contexts, such as conformity, aggression, or cooperation. Meanwhile, social cognition researchers investigated how people perceive, interpret, and mentally represent their social environments. However, modern perspectives no...
376
01:21Cognitive Learning
1.2K
Cognitive learning is based on purposive behavior, incidental learning, and insight learning.
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
1.2K