When nucleoside chemistry met hypervalent iodine reagents

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Nucleoside Chemistry

Background:

• Hypervalent iodine reagents have emerged as versatile tools in organic synthesis.
• Nucleoside chemistry is crucial for developing therapeutic agents and understanding biological processes.

Purpose of the Study:

• To review the applications of hypervalent iodine reagents in nucleoside chemistry.
• To highlight key synthetic transformations and novel nucleoside analogues developed between 2003 and 2017.

Main Methods:

• Literature review of published research from 2003-2017.
• Focus on studies utilizing hypervalent iodine reagents in nucleoside synthesis.

Main Results:

• Synthesis of nucleoside analogues with sulfur and seleno sugar surrogates.
• Construction of unusual carbocyclic and ether ring-containing nucleosides.
• Introduction of sulfur and selenium into nucleoside bases and synthesis of heterocyclic nucleoside analogues.

Conclusions:

• Hypervalent iodine reagents offer efficient and selective methods for nucleoside modification and analogue synthesis.
• These reagents facilitate the creation of diverse nucleoside structures with potential biological activities.
• The reviewed period shows significant advancements in leveraging hypervalent iodine chemistry for nucleoside research.