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Updated: Feb 5, 2026

Detecting Cortex Fragments During Bacterial Spore Germination
Published on: June 25, 2016
Detection of m
Xing-Bo Mo1,2,3, Shu-Feng Lei1,2,3, Yong-Hong Zhang1,3
1Jiangsu Key Laboratory of Preventive & Translational Medicine for Geriatric Diseases, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, PR China.
Aim:
To investigate the effects of m6A-single nucleotide polymorphisms (SNPs) on coronary artery disease (CAD).
Methods:
We examined the association of m6A-SNPs with CAD in about 185,000 cases and controls and further performed eQTL and differential expression analyses to support the identified m6A-SNPs.
Results:
Among the 4390 m6A-SNPs detected, 304 seemed to be associated with CAD (p < 0.05). SNP rs12286 was significantly associated with CAD at genome-wide level (p = 4.5 × 10-9). rs12286 was predicted to influence m6A methylation and have the potential to alter regulatory motifs binding, which may in turn regulate the expression of ADAMTS7 (p = 1.26 × 10-8).
Conclusion:
The present study found plenty of CAD-associated m6A-SNPs and demonstrated the potential functionality of the identified SNPs.
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