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[Corrigendum] Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis
Haiying Shen1, Kiyoon Kim1, Yoojung Oh1
1Department of Biochemistry and Molecular Biology (BK21 Project), Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea.
Abstract:
Following the publication of the above article and a Corrigendum published in July 2018, the authors have noted an additional error, associated with the presentation of Fig. 1C. Fig 1C showed that β‑N‑methylamino‑L‑alanine induces neuronal apoptotic cell death; however, an error was made in the compilation of this figure and an incorrect band image was selected for α‑actinin, the loading control panel for Fig. 1C. A corrected version of Fig. 1 is shown opposite, incorporating the correct α‑actinin protein bands in Fig. 1C. This change affects neither the interpretation of the data nor conclusions of this work. We regret that this further error went unnoticed at the time, and thank the Editor for allowing us the opportunity to publish this additional Corrigendum. [the original article was published in the Molecular Medicine Reports 14: 4873‑4880, 2016; DOI: 10.3892/mmr.2016.5802].
Insights
This corrigendum corrects an error in Fig. 1C of a previous study on β‑N‑methylamino‑L‑alanine (BMAA) and neuronal apoptosis. The corrected figure ensures accurate representation of α‑actinin loading controls, without altering study conclusions.
Area of Science:
- Neuroscience
- Cell Biology
- Toxicology
Background:
- The original study investigated the role of β‑N‑methylamino‑L‑alanine (BMAA) in inducing neuronal apoptotic cell death.
- Previous publications included a corrigendum in July 2018, addressing earlier errors.
Purpose of the Study:
- To correct an error in the presentation of Figure 1C within the original publication.
- To provide a corrected version of Figure 1C, ensuring accurate loading control data.
Main Methods:
- The error involved the selection of an incorrect band image for α‑actinin, used as a loading control in Figure 1C.
- A corrected version of Figure 1 is presented, featuring the accurate α‑actinin protein bands for Figure 1C.
Main Results:
- The corrected Figure 1C accurately displays the α‑actinin loading control bands.
- The correction does not impact the interpretation of the experimental data presented in the original study.
Conclusions:
- The findings and conclusions of the original research remain valid despite the identified figure error.
- This corrigendum ensures the integrity and accuracy of the published scientific record regarding BMAA-induced neuronal apoptosis.
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