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Pretreatment

Yoko Satoh1,2, Utaroh Motosugi2, Akitoshi Saito3

  • 11 Yamanashi PET Imaging Clinic, Kofu Neurosurgical Hospital, Chuo City, Yamanashi Prefecture, Japan.

Technology in Cancer Research & Treatment
|September 18, 2018
PubMed
Summary
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Fluorodeoxyglucose uptake in lung parenchyma is a significant predictor of survival in stage I non-small cell lung cancer patients treated with stereotactic body radiation therapy. Subclinical interstitial lung disease did not impact survival outcomes in this cohort.

Area of Science:

  • Oncology
  • Radiotherapy
  • Pulmonary Medicine

Background:

  • Stereotactic body radiation therapy (SBRT) is a standard treatment for early-stage non-small cell lung cancer (NSCLC).
  • Predicting survival outcomes in NSCLC patients undergoing SBRT is crucial for treatment planning and patient management.
  • The role of pre-treatment imaging biomarkers, such as fluorodeoxyglucose (FDG) uptake and interstitial lung disease (ILD), in predicting SBRT outcomes requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic value of lung parenchyma fluorodeoxyglucose (FDG) uptake and subclinical interstitial lung disease (ILD) on computed tomography (CT).
  • To determine their predictive value for survival in patients with stage I non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT).

Main Methods:

Keywords:
FDG uptakePET/CTSBRTlung cancerlung parenchyma

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  • Retrospective analysis of 125 stage I NSCLC patients treated with SBRT.
  • Quantification of FDG uptake in lung parenchyma using tissue fraction-corrected standardized uptake value (TC-SUV) from FDG-PET/CT.
  • Radiological assessment of subclinical ILD on CT scans; survival analyses performed using Kaplan-Meier and Cox regression models.

Main Results:

  • The 3-year overall survival rate was 67.9% and progression-free survival was 52.0%.
  • Multivariate analysis revealed that TC-SUV was significantly correlated with overall survival (P = .027, HR: 2.694).
  • Subclinical ILD showed no significant correlation with overall survival (P = .535, HR: 1.256).

Conclusions:

  • Lung parenchyma FDG uptake, quantified as TC-SUV, is an independent prognostic factor for overall survival in stage I NSCLC patients receiving SBRT.
  • Subclinical ILD identified on CT scans does not appear to be a significant predictor of survival in this patient group.
  • TC-SUV may serve as a valuable imaging biomarker to personalize SBRT treatment strategies for early-stage NSCLC.