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Updated: Feb 5, 2026

Cytotoxicity Assays with Zebrafish Cell Lines
Published on: January 6, 2023
From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis
Ekaterina V Svezhentseva1,2, Yuri A Vorotnikov1, Anastasiya O Solovieva3,4
1Nikolaev Institute of Inorganic Chemistry SB RAS, 3 acad. Lavrentiev ave., 630090, Novosibirsk, Russia.
Abstract:
Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6 I8 }(DMSO)6 ](NO3 )4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.
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