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Updated: Feb 5, 2026

Robotic Ablation of Atrial Fibrillation
Published on: May 29, 2015
Disease progression after ablation for atrial flutter compared with atrial fibrillation: A nationwide cohort study
Flemming Skjøth1,2, Henrik Vadmann3, Søren Pihlkjaer Hjortshøj3
1Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark.
Insights
Atrial flutter ablation is linked to higher mortality and heart failure risk compared to atrial fibrillation ablation. Patients undergoing flutter ablation also experienced more renewed arrhythmias and pacemaker implantations.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Databases
Background:
- Atrial flutter and atrial fibrillation (AF) are common arrhythmias requiring ablation.
- Comparative outcomes between atrial flutter ablation and AF ablation are not well-established.
Purpose of the Study:
- To compare the risk of death, arrhythmia recurrence, and heart failure development after atrial flutter ablation versus AF ablation.
Main Methods:
- Observational study using Danish nationwide health databases (2000-2016).
- Included patients with first-time ablation for atrial flutter or AF.
- Compared rates of renewed arrhythmia, heart failure, and death using adjusted hazard ratios (HR).
Main Results:
- Higher all-cause mortality in atrial flutter patients (HR 1.80).
- Increased risk of heart failure post-ablation in atrial flutter (HR 1.48).
- More frequent renewed atrial flutter ablation (HR 2.42) and pacemaker implantations (HR 1.42) in the atrial flutter group.
Conclusions:
- Atrial flutter ablation is associated with a higher risk of mortality and heart failure compared to AF ablation.
- Patients undergoing atrial flutter ablation face greater risks of arrhythmia recurrence and need for further interventions.
Aims:
The aim of this study was to study the risk of death and development of arrhythmia and/or subsequently heart failure after an atrial flutter ablation procedure compared with an atrial fibrillation (AF) ablation procedure.
Methods:
This observational study is based on data from Danish nationwide health databases. Patients with a first-time ablation procedure for either atrial flutter or AF in the period 2000-2016 were included. Rates of renewed arrhythmia, heart failure or death were compared and reported as adjusted hazard ratios (HR).
Results:
The study population consisted of 2,004 and 3,803 patients with an incident atrial flutter or AF ablation procedure, respectively. All-cause mortality among atrial flutter patients was significantly higher compared with the AF group (HR 1.80, 95% confidence interval [CI] 1.39-2.35). The incidence of renewed arrhythmia without heart failure was lower in atrial flutter (HR 0.76, 95% CI 0.69-0.84). Renewed atrial flutter ablation and pacemaker implantations were significantly more frequent (HR 2.42, 95% CI 2.02-2.91 and HR 1.42, 95% CI 1.13-1.79, respectively) in atrial flutter compared with AF. The risk of heart failure was higher for atrial flutter, both after the initial ablation (HR 1.48, 95% CI 1.08-2.03), and after a further arrhythmia management event (HR 1.98, 95% CI 1.33-2.94).
Conclusion:
There was a higher mortality risk after atrial flutter ablation procedures compared with patients undergoing AF ablation. Rates of heart failure and further renewed (non-AF) arrhythmia management were higher in atrial flutter.
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