Disease progression after ablation for atrial flutter compared with atrial fibrillation: A nationwide cohort study

Flemming Skjøth1,2, Henrik Vadmann3, Søren Pihlkjaer Hjortshøj3

  • 1Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark.

Insights

Atrial flutter ablation is linked to higher mortality and heart failure risk compared to atrial fibrillation ablation. Patients undergoing flutter ablation also experienced more renewed arrhythmias and pacemaker implantations.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Databases

Background:

  • Atrial flutter and atrial fibrillation (AF) are common arrhythmias requiring ablation.
  • Comparative outcomes between atrial flutter ablation and AF ablation are not well-established.

Purpose of the Study:

  • To compare the risk of death, arrhythmia recurrence, and heart failure development after atrial flutter ablation versus AF ablation.

Main Methods:

  • Observational study using Danish nationwide health databases (2000-2016).
  • Included patients with first-time ablation for atrial flutter or AF.
  • Compared rates of renewed arrhythmia, heart failure, and death using adjusted hazard ratios (HR).

Main Results:

  • Higher all-cause mortality in atrial flutter patients (HR 1.80).
  • Increased risk of heart failure post-ablation in atrial flutter (HR 1.48).
  • More frequent renewed atrial flutter ablation (HR 2.42) and pacemaker implantations (HR 1.42) in the atrial flutter group.

Conclusions:

  • Atrial flutter ablation is associated with a higher risk of mortality and heart failure compared to AF ablation.
  • Patients undergoing atrial flutter ablation face greater risks of arrhythmia recurrence and need for further interventions.
Abstract

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.0K
Amyloid Fibrils03:03

Amyloid Fibrils

6.4K
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
571
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.8K