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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Related Experiment Video

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Author Spotlight: Developing a Reproducible Method for Isolating Bone Marrow-Derived Macrophages from Neonatal Mice to Advance Early Life Immune Responses
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Bone Marrow Chimeras to Study Neuroinflammation.

Nathalie Laflamme1, Paul Préfontaine1, Antoine Lampron1

  • 1Neuroscience Laboratory, CHU de Québec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec, Canada.

Current Protocols in Immunology
|September 18, 2018
PubMed
Summary

This study details bone marrow transplantation (BMT) protocols in mice for studying brain conditions. It covers recipient preparation, donor cell selection, and analysis techniques for hematopoietic cell research.

Keywords:
bone marrowcentral nervous systemchemotherapychimeric micehematopoietic systemirradiationmyeloablationtransplantation

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Area of Science:

  • Hematology
  • Neuroscience
  • Immunology

Background:

  • Bone marrow transplantation (BMT) is crucial for treating diseases like leukemia and inherited metabolic disorders.
  • Mouse models are essential for studying hematopoietic cell homing and function.
  • Chimeric mice, with distinct hematopoietic systems, are valuable research tools.

Purpose of the Study:

  • To provide a detailed protocol for bone marrow transplantation in mouse models.
  • To enable studies of the brain under normal and pathological conditions using BMT.
  • To outline methods for creating and analyzing chimeric mice for neuroscience research.

Main Methods:

  • Recipient mice preparation via irradiation or chemotherapy.
  • Isolation and injection of donor hematopoietic stem cells.
  • Analytical techniques including fluorescence-activated cell sorting (FACS) and immunostaining.

Main Results:

  • Established protocols for successful bone marrow transplantation in mice.
  • Demonstrated the utility of BMT for creating chimeric mice for brain research.
  • Provided a framework for analyzing cell engraftment and distribution.

Conclusions:

  • Bone marrow transplantation is a versatile technique for neurological and hematopoietic research in mice.
  • The described methods facilitate the study of hematopoietic cell behavior in the brain.
  • This protocol supports investigations into BMT for various neurological and systemic diseases.