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Measurement of Bioelectric Current with a Vibrating Probe

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Globus: Current Concepts and Dilemmas.

José Tawil¹, Ronnie Fass²

¹Esophageal and Functional GI Disorders Division, Gedyt, Diagnostic & Therapeutic Gastroenterology and Endoscopy, Buenos Aires, Argentina.

Journal of Clinical Gastroenterology

|September 18, 2018

Summary

Globus sensation, often unexplained, affects multiple medical fields. Identifying the cause requires investigating structural or functional issues, with treatments varying from addressing organic causes to neuromodulators for functional disorders.

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Area of Science:

Gastroenterology and Otolaryngology
Investigating the complex etiology of globus sensation.

Background:

Globus sensation is a common condition of interest to various medical specialists.
Despite thorough investigation, the underlying cause of globus often remains unidentified.
Patients frequently seek care across multiple specialties without symptom resolution.

Purpose of the Study:

To explore the diverse potential causes of globus sensation.
To highlight the diagnostic challenges in identifying the etiology of globus.
To review current understanding of globus pathophysiology and treatment approaches.

Main Methods:

Review of literature concerning globus sensation.
Discussion of diagnostic investigations for structural and functional abnormalities of the upper aerodigestive tract.
Analysis of potential contributing factors including gastroesophageal reflux disease, esophageal inlet patches, and oropharyngeal hypersensitivity.

Main Results:

Gastroesophageal reflux disease is a frequently suspected cause identified during ear, nose, and throat evaluations.
Esophageal inlet patches have emerged as a potential contributor, with their removal sometimes resolving symptoms.
Globus can be linked to psychiatric disorders and oropharyngeal hypersensitivity (chemical or mechanical).

Conclusions:

Diagnosis of globus requires a comprehensive evaluation of the thyroid, larynx, pharynx, and esophagus.
Treatment strategies are tailored to the identified cause, whether organic or functional.
For functional globus, neuromodulators and psychological interventions are primary therapeutic options.