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Ocular involvement in atopic disease: a review
Nimesh Patel1, Nandini Venkateswaran1, Ziqi Wang2
1Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami.
Current Opinion in Ophthalmology
|September 18, 2018
Summary
Atopic keratoconjunctivitis (AKC) is a serious eye condition that can lead to blindness. Early, multidisciplinary treatment is crucial for managing this chronic inflammatory disease and preserving vision, especially in young patients.
Area of Science:
- Ophthalmology
- Allergy and Immunology
- Dermatology
Background:
- Atopic disease frequently involves the eyes, potentially leading to serious complications.
- Atopic keratoconjunctivitis (AKC) is increasingly recognized as a chronic, inflammatory condition with a risk of vision loss.
Purpose of the Study:
- To review the sight-threatening complications of ocular atopic disease.
- To discuss management strategies for this chronic condition.
Main Methods:
- This review synthesizes current understanding and treatment approaches for ocular atopic disease.
Main Results:
- Ocular involvement in atopy presents with diverse clinical signs.
- Severe atopic keratoconjunctivitis (AKC) is a chronic, inflammatory, and potentially blinding disease.
- Emerging treatments include steroid-sparing, systemic T-cell, and calcineurin inhibitor medications for severe cases.
Conclusions:
- Progressive ocular atopic disease poses a significant threat to vision, particularly in pediatric populations.
- A multidisciplinary approach involving ophthalmology, allergy, immunology, and dermatology is essential for effective disease management.
- Prompt and consistent treatment can lead to disease stability and prevent vision loss.
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