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Evolutionary considerations on 5-HT

Imane Moutkine1, Emily Lauren Collins1, Catherine Béchade1

  • 1INSERM UMR-S839, Paris, 75005, France; Sorbonne Université, Paris, 75005, France; Institut du Fer à Moulin, Paris, 75005, France.

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|September 18, 2018
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Summary
This summary is machine-generated.

The serotonin 5-HT2B receptor gene (Htr2b) and the proteasome subunit gene (Psmd1) show ancient genomic association. This suggests Htr2b may be the ancestral gene for serotonin 5-HT2A/2B/2C receptors, impacting basic physiological functions.

Keywords:
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Area of Science:

  • Evolutionary biology
  • Neuroscience
  • Genetics

Background:

  • Serotonin is a conserved neurotransmitter crucial for nervous system development and function.
  • Serotonin receptor subtypes diversified with vertebrate evolution, highlighting their biological and clinical importance.
  • The 5-HT2B receptor (Htr2b) plays roles in embryonic development, including neural crest and cardiac embryogenesis.

Purpose of the Study:

  • To review the evolutionary history of serotonin receptors.
  • To investigate the genomic association between the RPN2 proteasome subunit gene (Psmd1) and the Htr2b gene.
  • To explore the implications of this association for serotonin receptor evolution and function.

Main Methods:

  • Literature review of existing data on genomic associations.
  • Analysis of gene conservation patterns during genome duplication events.
  • Comparative genomics of serotonin receptor genes.

Main Results:

  • Evidence suggests a conserved genomic association between Psmd1 and Htr2b since pre-vertebrate evolution.
  • This conserved linkage implies strong selective pressure, possibly indicating a single conserved copy during genome duplications.
  • The evolutionary association suggests Htr2b may be the ancestral gene for the 5-HT2A/2B/2C receptor subfamily.

Conclusions:

  • The ancient association between Psmd1 and Htr2b may underpin fundamental physiological roles of the serotonin system.
  • Understanding this evolutionary link offers insights into the pathophysiology of serotonin-related disorders.
  • Htr2b's potential role as an ancestral receptor warrants further investigation into the 5-HT2A/2B/2C subfamily's evolution.