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Updated: Feb 5, 2026
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Diagnostic and prognostic value of serum miR-99a expression in oral squamous cell carcinoma
Liang Chen1,1, Jing Hu2,1, Lina Pan1
1Department of Endodontics, Jinan Stomatological Hospital, Jinan, Shandong, China.
Background:
Despite progress in the treatment of oral squamous cell carcinoma (OSCC) over past years, the prognosis for OSCC patients remains dismal. MicroRNA-99a (miR-99a) has been found to involve in the development of many cancer types, but its clinical role in OSCC is unclear.
Objective:
The aim of this study was to explore the clinical implications of serum miR-99a in OSCC.
Methods:
This study detected serum miR-99a levels in 121 OSCC cases and 55 healthy controls by using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis.
Results:
The data showed that serum miR-99a expression was significantly decreased in OSCC patients compared with normal controls. OSCC patients with low miR-99a expression experienced more frequent poor differentiation and advanced clinical stage. Furthermore, in screening OSCC cases from normal controls, miR-99a could yield a receiver-operating characteristic (ROC) area under the curve (AUC) of 0.911 with 83.6% specificity and 80.2% sensitivity. Notably, patients with high miR-99a expression had longer overall survival and recurrence free survival. Finally, serum miR-99a was identified to be an independent prognostic indicator for OSCC.
Conclusions:
These results suggested that miR-99a might be a valuable marker for the prediction of early detection and prognosis in OSCC.
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