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Updated: Feb 5, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

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Antibody drug conjugates: Progress, pitfalls, and promises

Anubhab Mukherjee1,2, Ariana K Waters1,2, Ivan Babic2

  • 1Drug Discovery and Nanomedicine Research Program, CA-90404, USA.

Human Antibodies
|September 19, 2018
PubMed

Insights

Antibody drug conjugates (ADCs) offer targeted cancer therapy by combining antibodies with drugs. Research is advancing, focusing on design and antigen selection for future ADC success.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Antibody drug conjugates (ADCs) are an effective targeted cancer therapy.
  • ADCs comprise a monoclonal antibody, a cytotoxic drug, and a linker for tumor selectivity.
  • Recent approvals have spurred significant research, with over 60 ADCs in clinical development.

Purpose of the Study:

  • To review the key components in designing antibody drug conjugates.
  • To discuss improvements and lessons learned in ADC research over two decades.
  • To explore the future of third-generation ADCs.

Main Methods:

  • Literature review of antibody drug conjugate research.
  • Analysis of ADC design principles and components.
  • Examination of historical data and future trends in ADC development.

Main Results:

  • ADCs provide targeted delivery, reduced toxicity, and enhanced stability.
  • Successful ADC design relies on specific antigen selection and optimized components.
  • Ongoing research focuses on overcoming challenges and advancing ADC technology.

Conclusions:

  • Antibody drug conjugates are a vital tool in targeted cancer therapy.
  • Continued research and careful design are crucial for the success of future ADCs.
  • The evolution of ADCs, including third-generation therapies, promises improved cancer treatment outcomes.
Keywords:
Monoclonal antibodiesantibody-drug conjugatescytotoxic drugslinkersite-specific drug conjugationtarget antigens

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