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Published on: April 30, 2015
Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert
Alejandro Ardiles1, Ruth Barrientos2, Mario J Simirgiotis3,4
1Departamento de Química y Farmacia, Facultad de Ciencias, Universidad Católica del Norte, Angamos 0610, Antofagasta 1240000, Chile. alejandro.ardiles@ucn.cl.
Abstract:
Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant.
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