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Related Experiment Video

Updated: Feb 5, 2026

Microfluidic Applications for Disposable Diagnostics
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The diagnostic value of [

Yu-Guang Tian1, Min Yue1, Bayaer Nashun2

  • 1Department of Laboratory Animal Center, Southern Medical University, 1838# Guangzhou North Road, Guangzhou, 510515, Guangdong, China.

Journal of Translational Medicine
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

18F-FDG PET/CT imaging can detect early kidney damage from total body irradiation (TBI). This metabolic imaging tool shows changes in glucose uptake, reflecting radiation-induced kidney injury and aiding in early diagnosis.

Keywords:
18F-FDG PET/CTKidneyRadiation damageRapid assessmentTibet minipigTotal body irradiation

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Area of Science:

  • Medical Imaging
  • Radiology
  • Nuclear Medicine

Background:

  • Radiation-induced kidney damage impairs renal function and glucose reabsorption.
  • 18F-FDG PET/CT is a standard for imaging glucose metabolism.
  • Assessing the diagnostic value of 18F-FDG PET/CT for hyperacute radiation effects on kidneys.

Purpose of the Study:

  • To evaluate the diagnostic utility of 18F-FDG PET/CT in detecting early kidney damage following total body irradiation (TBI).
  • To correlate metabolic changes observed via PET/CT with histological and functional renal alterations.

Main Methods:

  • Tibet minipigs underwent TBI with varying X-ray dosages.
  • Whole-body 18F-FDG PET/CT scans were performed at 6, 24, and 72 hours post-TBI.
  • Histological examination, blood analysis, and renal function tests were conducted.

Main Results:

  • Significant differences in 18F-FDG uptake were observed in TBI groups (11/14 Gy) compared to controls, peaking at 72 hours post-14 Gy TBI.
  • Doses over 8 Gy induced tubular damage, inflammation, and mitochondrial changes.
  • Renal function markers (BUN, creatinine) and inflammatory cytokine expression (IL-10, TNF-α) correlated with radiation dose.

Conclusions:

  • 18F-FDG PET/CT effectively reflects radiation-induced kidney pathology.
  • This imaging modality shows promise for rapid, non-invasive assessment of radiation nephropathy.