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Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
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Reversal of Systemic Anticoagulants and Antiplatelet Therapeutics

David Dornbos1, Shahid M Nimjee1

  • 1Department of Neurological Surgery, Ohio State University Medical Center, N-1014 Doan Hall, 410 West 10th Avenue, Columbus, OH, USA.

Neurosurgery Clinics of North America
|September 19, 2018
PubMed

Insights

Managing antiplatelet and anticoagulant medications is crucial for neurosurgical patients facing bleeding risks or needing urgent procedures. This review details current therapies and emergency reversal strategies for these antithrombotic agents.

Area of Science:

  • Neurosurgery
  • Cardiology
  • Hematology

Background:

  • Antiplatelet and anticoagulant medications are vital for cardiac conditions, stroke prevention, and venous thromboembolic events.
  • These medications present a significant challenge in neurosurgical settings, especially with intracranial hemorrhage or before emergency procedures.

Purpose of the Study:

  • To provide a comprehensive summary of current antiplatelet and anticoagulant therapies.
  • To review the role of emergency reversal strategies for these medications in neurosurgical patients.

Main Methods:

  • Literature review of current antiplatelet and anticoagulant therapies.
  • Analysis of emergency reversal strategies and their application in neurosurgical procedures.

Main Results:

  • Many current antithrombotic therapies lack direct reversal agents.
  • Various strategies exist to reverse or mitigate the effects of antiplatelet and anticoagulant drugs.

Conclusions:

  • Effective management of antithrombotic agents is critical for neurosurgical patient safety.
  • Understanding emergency reversal options is essential for mitigating bleeding risks in neurosurgery.

Keywords:
Anti-plateletAnticoagulationIntracranial hemorrhageStroke

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