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Surgery in perforated pediatric intestinal lymphoma

Gehad Ahmed1, Maged ElShafiey2, Hany Abdelrahman3

  • 1Department of Surgery, Faculty of Medicine, Helwan University, Egypt; Surgical Oncology Department, Children's Cancer Hospital, 57357, Egypt (CCHE), Egypt.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|September 19, 2018
PubMed

Insights

Perforation in pediatric intestinal lymphoma is common but not a poor prognostic sign. Primary resection and anastomosis are safe surgical options for these young patients when complete tumor removal is possible.

Area of Science:

  • Pediatric oncology
  • Surgical oncology
  • Gastrointestinal surgery

Background:

  • Perforation is the most frequent surgical complication in pediatric intestinal lymphoma.
  • Surgical management decisions for this condition are often debated.

Purpose of the Study:

  • To evaluate the outcomes of surgical interventions for perforated pediatric intestinal lymphoma.
  • To identify risk factors associated with perforation and analyze management strategies.

Main Methods:

  • Retrospective analysis of pediatric patients (<18 years) with intestinal lymphoma from July 2007 to June 2017.
  • Analysis included risk factors for perforation, management types, and outcomes in perforated cases.

Main Results:

  • 16 out of 240 patients (6.7%) experienced intestinal perforation, most commonly in the ileum and associated with Burkitt lymphoma.
  • Primary resection and anastomosis were performed in 12 patients; common postoperative complications included wound infection and dehiscence.
  • Five-year survival rates for perforated patients (78.6% overall, 71.4% event-free) were comparable to non-perforated patients (85.5% overall, 81.2% event-free), with no significant difference.

Conclusions:

  • Intestinal perforation is not a negative prognostic indicator for survival in pediatric intestinal lymphoma.
  • Primary resection with anastomosis is a viable and safe surgical approach when complete tumor resection is achievable.
Abstract

Keywords:
Intestinal lymphomaPediatricsPerforation

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