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Non-coding RNA in drug resistance of hepatocellular carcinoma

Bisha Ding1,2,3, Weiyang Lou1,2,3, Liang Xu1,2,3

  • 1Program of Innovative Cancer Therapeutics, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

Bioscience Reports
|September 19, 2018
PubMed

Insights

Drug resistance significantly impacts chemotherapy effectiveness in hepatocellular carcinoma (HCC). Non-coding RNAs (ncRNAs) are crucial in HCC chemoresistance and hold potential as diagnostic and therapeutic biomarkers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Hepatocellular carcinoma (HCC) is a lethal cancer with poor chemotherapy outcomes due to drug resistance.
  • Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, are implicated in cancer development and progression.
  • Emerging research highlights the critical role of ncRNAs in mediating chemoresistance in HCC.

Purpose of the Study:

  • To review current findings on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in HCC drug resistance.
  • To summarize the mechanisms by which ncRNAs modulate chemoresistance in HCC.
  • To discuss the future clinical applications of ncRNAs in overcoming HCC chemoresistance.

Main Methods:

  • Literature review of recent studies on ncRNAs and HCC chemoresistance.
  • Analysis of mechanisms involving miRNA and lncRNA in modulating drug resistance.
  • Discussion of clinical potential and future directions.

Main Results:

  • ncRNAs play significant roles in the development and progression of HCC chemoresistance.
  • Specific miRNAs and lncRNAs have been identified as key regulators of drug resistance in HCC.
  • ncRNAs show promise as biomarkers for HCC diagnosis, treatment, and prognosis.

Conclusions:

  • ncRNAs are pivotal in HCC chemoresistance, offering potential therapeutic targets.
  • Understanding ncRNA mechanisms can lead to strategies to overcome drug resistance in HCC.
  • ncRNAs represent a promising avenue for improving HCC patient outcomes and clinical management.
Keywords:
HCCchemoresistancedrug resistancehepatocellular carcinomalong non-coding RNAmicroRNA

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