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Updated: Feb 5, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Beyond Penicillin: Rapid Desensitization for Specific Flucloxacillin Hypersensitivity
J C Kwong1, K Urbancic1,2,3, J A Trubiano4,5,3
1Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
Abstract:
Beta-lactam therapy for severe staphylococcal infections is associated with superior outcomes, compared to non-beta-lactam therapy. For patients with immediate hypersensitivity to beta-lactams, desensitization has been widely employed to allow beta-lactam therapy, but published protocols for antistaphylococcal beta-lactams such as flucloxacillin are lacking. Here, we report a case and describe the desensitization protocol successfully used for a patient with isolated flucloxacillin immediate hypersensitivity, for whom a penicillin desensitization protocol would likely have resulted in an adverse drug reaction.
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