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Updated: Feb 5, 2026

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
Detection, Characterization, and Clinical Application of Mesenchymal Stem Cells in Periodontal Ligament Tissue
Atsushi Tomokiyo1, Shinichiro Yoshida1, Sayuri Hamano2,3
1Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.
Abstract:
Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.
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