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Related Experiment Videos

[Malignant fibrous histiocytomas].

C Kallweit, B Pfeiff, H Pullmann

    Zeitschrift Fur Hautkrankheiten
    |September 15, 1986
    PubMed
    Summary
    This summary is machine-generated.

    This study reports two cases of malignant fibrous histiocytoma (MFH) of the storiform pleomorphic type in the lower legs. These rare tumors arose in distinct clinical contexts, highlighting varied etiologies.

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    Serum antibody titers in a systemic lytic therapy with streptokinase.

    Southern medical journal·1998

    Area of Science:

    • Oncology
    • Surgical Pathology
    • Dermatopathology

    Background:

    • Malignant fibrous histiocytoma (MFH), now often reclassified under broader sarcoma categories, presents diagnostic challenges.
    • Pleomorphic storiform MFH is a subtype requiring careful differentiation from other soft tissue neoplasms.

    Observation:

    • Two cases of pleomorphic storiform MFH in the lower extremities of a 79-year-old and a 42-year-old patient are presented.
    • The first tumor occurred in proximity to a pre-existing superficial peroneal nerve paresis.
    • The second tumor developed within a chronic, childhood-onset fistulous osteomyelitis.

    Findings:

    • Histopathological examination confirmed malignant fibrous histiocytoma, storiform pleomorphic type.
    • Differential diagnoses considered included dermatofibrosarcoma protuberans and squamous cell carcinoma.

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  • The specific locations and associated conditions provide unique insights into potential tumor development pathways.

    • Implications:

    • These cases underscore the importance of considering MFH in lower limb soft tissue lesions, especially with atypical presentations.
    • Understanding the association with nerve injury and chronic inflammation may inform future research into MFH pathogenesis.
    • Accurate diagnosis is crucial for appropriate patient management and treatment strategies for these rare sarcomas.