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Interaction between spin labels and DPPC vesicles.

W Lohmann, B Kiefer, W Schmehl

    Zeitschrift Fur Naturforschung. C, Journal of Biosciences
    |July 1, 1986
    PubMed
    Summary
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    Spin labels alter dipalmitoylphosphatidylcholine (DPPC) vesicle structure over time. Vitamin C (Na-ascorbate) appears to stabilize these membranes, suggesting a potential therapeutic role.

    Area of Science:

    • Biophysics
    • Membrane Biophysics
    • Lipid Bilayer Dynamics

    Background:

    • Dipalmitoylphosphatidylcholine (DPPC) forms the primary structure of cell membranes.
    • Spin labels are crucial tools for probing membrane dynamics and structure.
    • Understanding lipid-protein interactions is key to cellular function.

    Purpose of the Study:

    • To investigate the effects of spin labels (1,14) and (12,3) on DPPC vesicle structure.
    • To determine the time-dependent changes induced by spin labels in vesicle membranes.
    • To explore the potential membrane-stabilizing effects of Na-ascorbate.

    Main Methods:

    • Electron Paramagnetic Resonance (EPR) spectroscopy using spin-labeled DPPC.
    • Proton Nuclear Magnetic Resonance (1H NMR) studies.

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  • Time-course analysis of vesicle structural changes post-preparation.

    • Main Results:

    • Both spin labels (1,14) and (12,3) influenced DPPC vesicle fatty acid side chains and choline head groups.
    • Spin label (12,3) showed a stronger effect on head groups, while (1,14) affected side chains more.
    • Na-ascorbate addition reversed spin label effects, indicating membrane stabilization.
    • ESR signals correlated with structural changes: high-field for side chains, low-field for head groups.
    • A potential head group phase transition was observed at low temperatures with spin label (1,14).

    Conclusions:

    • Spin labels induce time-dependent structural modifications in DPPC vesicles.
    • Vitamin C (Na-ascorbate) exhibits a stabilizing effect on lipid membranes.
    • EPR spectral features provide insights into specific membrane region modifications.
    • Evidence suggests a possible phase transition in DPPC head groups under specific conditions.