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Identification of 16,25-

Wenxue Wang^1,2,3,4, Haoran Yang^1,2,3,4, Ying Li^2,3,4

¹School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, Shandong, People's Republic of China.

Royal Society Open Science

|September 19, 2018

Summary

This summary is machine-generated.

New compounds from Hemsleya pengxianensis var. jinfushanensis tubers show potential against human colon cancer. Compounds 8 and 9 inhibited cancer cell proliferation and induced apoptosis, suggesting a therapeutic option.

Keywords:

Cucurbitaceae Hemsleya pengxianensis anti-cancer cucurbitane triterpenoid

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Area of Science:

Natural Products Chemistry
Pharmacology

Background:

Hemsleya pengxianensis var. jinfushanensis tubers are a source of bioactive compounds.
Colon cancer remains a significant global health challenge requiring novel therapeutic strategies.

Purpose of the Study:

To isolate and characterize new cucurbitane glucosides from Hemsleya pengxianensis var. jinfushanensis.
To evaluate the anti-cancer effects of isolated compounds on human colon cancer cells.

Main Methods:

Isolation and structural elucidation of compounds using spectroscopic techniques (IR, NMR, HR-ESI-MS).
In vitro anti-cancer assays on HT29 human colon cancer cells.
Analysis of cell proliferation, cell cycle, apoptosis, and F-actin aggregation.

Main Results:

Seven new cucurbitane glucosides (hemslepensides J-P) and two known compounds were isolated.
Compounds 8 and 9 significantly inhibited HT29 cell proliferation.
Compounds 8 and 9 induced F-actin aggregation, G2/M cell cycle arrest, and apoptosis in HT29 cells.

Conclusions:

The study expands the known chemical diversity of Hemsleya pengxianensis.
Compounds 8 and 9 demonstrate promising anti-colon cancer activity, warranting further investigation as potential therapeutic agents.