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Inhibitory Activity and Docking Analysis of Antimalarial Agents from

Pratiwi Pudjiastuti1, Ni Nyoman T Puspaningsih1, Imam Siswanto1

  • 1Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, Indonesia.

Journal of Parasitology Research
|September 19, 2018
PubMed
Summary

Certain alkaloids from Stemona roots, like croomine, show potential as antimalarial agents by inhibiting Plasmodium falciparum ferredoxin-NADP+ reductases (PfFNR). Croomine effectively blocks electron transfer in PfFNR, suggesting a new therapeutic avenue.

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