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Cong Zhou1, Ranran Pan1, Haochang Hu1

  • 1Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.

Peerj
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

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TNFRSF10C promoter hypermethylation is significantly associated with colorectal cancer (CRC) risk. This finding, validated in two stages, suggests its potential as a predictive biomarker for CRC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genomics

Background:

  • Abnormal methylation of TNFRSF10C is linked to various cancers.
  • Its role in colorectal cancer (CRC) was previously unestablished.

Purpose of the Study:

  • To investigate the association between TNFRSF10C methylation and CRC.
  • To evaluate TNFRSF10C methylation as a potential biomarker for CRC risk.

Main Methods:

  • Quantitative methylation specific PCR (qMSP) and Percentage of Methylated Reference (PMR) were used.
  • Two-stage study involving tumor and adjacent non-tumor tissues (discovery: 38 pairs, validation: 69 pairs).
  • Dual-luciferase reporter gene assay and TCGA data analysis were performed.

Main Results:

Keywords:
Colorectal cancerDNA methylationPromoterTNFRSF10C

Related Experiment Videos

  • Significant TNFRSF10C promoter hypermethylation was found in CRC tissues (P < 0.003).
  • TCGA data confirmed the association (P < 1E-7).
  • Hypermethylation correlated with lower TNFRSF10C expression and predicted shorter overall survival in CRC patients (P = 0.032).

Conclusions:

  • TNFRSF10C hypermethylation is significantly associated with CRC risk.
  • TNFRSF10C promoter hypermethylation may serve as a predictive biomarker for CRC.