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Influence of polymorphisms in

Xiao-Jun Lei1, Yong-Xia Zhao2, Tong Qiao3

  • 1Department of Ophthalmology, Friendship Hospital of Dalian, Dalian 116000, Liaoning Province, China.

International Journal of Ophthalmology
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

Genetic variations in ACE and TNF influence retinopathy of prematurity (ROP) risk in Chinese infants. ACE insertion deletion (ID) offers protection, while TNF -308G/A increases ROP susceptibility.

Keywords:
inflammationoxidationpolymorphismsretinopathy of prematurityvascularization

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Area of Science:

  • Genetics
  • Ophthalmology
  • Neonatology

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Genetic factors are implicated in ROP development, but specific gene associations require further investigation.

Purpose of the Study:

  • To examine the association between common polymorphisms in VEGF, ACE, TNF, and GST genes and the risk of retinopathy of prematurity (ROP) in Chinese infants.

Main Methods:

  • Genotyping of nine polymorphisms across VEGF, ACE, TNF, and GST genes in 724 ROP cases and 878 control infants.
  • Comparative analysis of polymorphism frequencies between ROP cases and controls to identify significant associations.

Main Results:

  • Two polymorphisms showed significant associations: ACE insertion deletion (ID) polymorphism and TNF -308G/A polymorphism.
  • ACE ID polymorphism was linked to a reduced ROP risk (P=0.031), while TNF -308G/A polymorphism was associated with an increased ROP risk (P<0.001).
  • Allele-level analysis confirmed these associations, with the ACE D allele decreasing risk and the TNF -308A allele increasing risk.

Conclusions:

  • The ACE ID polymorphism demonstrates a protective effect against ROP development in Chinese infants.
  • The TNF -308G/A polymorphism is identified as a risk factor for ROP in this population.