Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Xavier Robert1, Josiane Kassis-Sahyoun1, Nicoletta Ceres1

  • 1Molecular Microbiology and Structural Biochemistry institute, UMR5086 CNRS Univ-Lyon, F-69367 Cedex 7, Lyon, France.

Data in Brief
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural evidence that RNA contributes to polymorphism of tau amyloid fibrils.

iScience·2026
Same author

Generation of Nano-Antibodies Targeting the SNMP1 Membrane Receptor of <i>Spodoptera littoralis</i> Using Extracellular Vesicles.

Journal of extracellular biology·2026
Same author

First characterization of insertions in the HIV-1 integrase-coding region from people with HIV.

The Journal of antimicrobial chemotherapy·2026
Same author

Effects of a psychoeducation program for relatives of patients with first-episode psychosis who have received psychoeducation: An observational study.

L'Encephale·2026
Same author

In Vitro and In Vivo Evaluation of Small-Molecule Disassemblers of Pathological Tau Fibrils.

ACS chemical neuroscience·2026
Same author

Genetic and structural aspects of amyloid diseases.

Science translational medicine·2025
Same journal

A harmonized fast-fashion garment-variant dataset for textile circularity and sustainability assessment.

Data in brief·2026
Same journal

Terahertz reflectivity dataset: Reading text on both sides of the page.

Data in brief·2026
Same journal

High-quality draft genome sequence data of <i>Levilactobacillus brevis</i> 3LB isolated from fermented milk koumiss.

Data in brief·2026
Same journal

Interview dataset: Encouraging the development of industrial symbiosis networks in Slovenia - transition to the circular economy.

Data in brief·2026
Same journal

Timeseries of multispectral and radar data and vegetation indices from Sentinel-1, Sentinel-2 and Landsat-8 at field scale.

Data in brief·2026
Same journal

BACI-VI-Bench: A dataset of variational inequality benchmark instances for multi-agent trade-network equilibrium.

Data in brief·2026
See all related articles

This study computed diffraction anisotropy for all Protein Data Bank entries to understand X-ray diffraction properties. The findings offer insights into crystal packing and protein physical characteristics.

Area of Science:

  • Structural Biology
  • Biophysics
  • Crystallography

Background:

  • Diffraction anisotropy in macromolecular crystallography is often linked to crystal packing.
  • However, this empirical rule has exceptions, necessitating further investigation.
  • Understanding these discrepancies is crucial for accurate structural determination.

Purpose of the Study:

  • To systematically compute and analyze diffraction anisotropy for the entire Protein Data Bank (PDB).
  • To correlate X-ray diffraction properties with real-space crystal packing metrics.
  • To investigate differences between soluble and membrane proteins regarding diffraction anisotropy.

Main Methods:

  • Computation of diffraction anisotropy for all PDB entries.
  • Extraction and calculation of relevant metrics: resolution, space groups, cell parameters, solvent content, crystal contacts, and ligand presence.
Keywords:
Diffraction anisotropyMacromolecule crystalsMembrane proteinsX-ray diffraction

Related Experiment Videos

  • Categorization of proteins into soluble, membrane (with subcategories), and other relevant groups.

    • Main Results:

    • A comprehensive dataset of diffraction anisotropy and associated metrics for the PDB is now available.
    • Comparison of diffraction properties between soluble and membrane proteins revealed distinct characteristics.
    • Analysis provided context for discrepancies between observed diffraction anisotropy and traditional packing models.

    Conclusions:

    • The generated database facilitates large-scale statistical analysis of diffraction anisotropy.
    • This resource aids in understanding the physical properties of proteins based on their crystallographic data.
    • The findings support further investigation into the relationship between crystal packing and diffraction behavior.