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Related Concept Videos

Frequency-dependent Selection01:21

Frequency-dependent Selection

24.1K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
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Long-term Depression01:05

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Case Studies01:22

Case Studies

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There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
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Nondisjunction01:29

Nondisjunction

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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Regression Toward the Mean01:52

Regression Toward the Mean

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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Related Experiment Video

Updated: Feb 5, 2026

Author Spotlight: Advancing Metabolomics Analysis of Rare Hematopoietic Stem Cells
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Author Spotlight: Advancing Metabolomics Analysis of Rare Hematopoietic Stem Cells

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A Rare

Yan Yang1, Shu-Kui Qin2, Jian Zhu3

  • 1Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, People's Republic of China.

Mayo Clinic Proceedings. Innovations, Quality & Outcomes
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

A rare Striatin-ALK fusion gene was identified in advanced non-small cell lung cancer (NSCLC). Treatment with crizotinib showed excellent response, highlighting its effectiveness for this uncommon ALK rearrangement.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Anaplastic Lymphoma Kinase (ALK) gene fusions are recognized drivers in non-small cell lung cancer (NSCLC).
Keywords:
MRI, magnetic resonance imagingNGS, next-generation sequencingNSCLC, non–small cell lung cancerSTRN, striatinTKI, tyrosine kinase inhibitorctDNA, circulating tumor DNA

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  • While EML4-ALK is common, data on rare ALK translocations and their response to ALK tyrosine kinase inhibitors are limited.
  • A patient with advanced NSCLC and prior treatment failure presented with a rare ALK fusion.