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Ethical Issues in Contemporary Clinical Genetics.

Genna Braverman1, Zachary E Shapiro2, Jonathan A Bernstein3

  • 1Department of Internal Medicine, New York Presbyterian - Columbia University Medical Center, New York, NY.

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|September 19, 2018
PubMed
Summary
This summary is machine-generated.

Clinical genetics is expanding, requiring healthcare providers to understand ethical principles for genetic testing. This guide covers informed consent, result return, and privacy for better patient care.

Keywords:
ACMG, American College of Medical Genetics and GenomicsAMA, American Medical AssociationCF, cystic fibrosisCLIA, Clinical Laboratory Improvement AmendmentsDTC, direct-to-consumerFDA, Food and Drug AdministrationGINA, Genetic Information Non-Discrimination Act

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Area of Science:

  • Clinical Genetics
  • Bioethics
  • Genomic Medicine

Background:

  • Genomic sequencing is increasingly accessible in clinical settings and direct-to-consumer services.
  • Patients with various diagnoses are more likely to discuss genetic testing with providers.
  • Ethical considerations are crucial for navigating clinical genetics.

Purpose of the Study:

  • To provide an overview of ethical concerns in clinical genetics.
  • To equip clinicians with tools to guide practice and patient navigation.
  • To cover ethical issues across pretesting, testing, and posttesting phases.

Main Methods:

  • Review of medical, legal, and historical perspectives.
  • Organization of ethical issues by patient care phases (pretesting, testing, posttesting).
  • Focus on clinical practice with consideration for research.

Main Results:

  • Key ethical topics include informed consent, return of results, and privacy/confidentiality.
  • Understanding ethical principles is essential for applying them to genetic testing.
  • Contextual landscape of genetic testing situations is considered.

Conclusions:

  • Clinicians need a grasp of ethical principles in clinical genetics.
  • Ethical guidance helps patients navigate complex medical-psychosocial issues.
  • This review provides a foundation for applying ethical principles in genetic testing.