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T-Wave Indices and Atherosclerosis.

Gary Tse1,2, George Bazoukis3, Leonardo Roever4

  • 1Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China. tseg@cuhk.edu.hk.

Current Atherosclerosis Reports
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

The Tpeak-Tend interval, a measure of heart repolarization, is prolonged in atherosclerotic conditions, predicting arrhythmias and sudden cardiac death. Normalization after revascularization suggests treatment success.

Keywords:
Arterial functionAtherosclerosisHypertensionInflammatory diseasesMortalityT-WavesVentricular remodeling

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiovascular Research

Background:

  • The Tpeak-Tend interval reflects ventricular repolarization dispersion.
  • Prolonged Tpeak-Tend is linked to ventricular arrhythmias and sudden cardiac death in pro-arrhythmic conditions.
  • Atherosclerotic diseases can impact cardiac repolarization.

Purpose of the Study:

  • To review alterations in the Tpeak-Tend interval in atherosclerotic and inflammatory arterial diseases.
  • To explore the relationship between Tpeak-Tend, arterial function, ventricular remodeling, and clinical outcomes.
  • To assess the predictive value of Tpeak-Tend for arrhythmias and mortality in atherosclerosis.

Main Methods:

  • Comprehensive literature review of studies on Tpeak-Tend in atherosclerosis.
  • Analysis of Tpeak-Tend alterations in conditions like hypertension, coronary artery disease, and coronary slow flow.
  • Correlation analysis between Tpeak-Tend, arterial stenosis, ventricular remodeling, and outcomes.

Main Results:

  • Patients with coronary atherosclerosis exhibit prolonged Tpeak-Tend intervals and Tpeak-Tend/QT ratios.
  • These intervals predict ventricular arrhythmias and sudden cardiac death.
  • Prolonged Tpeak-Tend correlates with disease severity, ventricular remodeling, and arterial dysfunction.

Conclusions:

  • Prolonged Tpeak-Tend is a significant finding in coronary atherosclerosis.
  • Tpeak-Tend serves as a predictor of adverse cardiac events and correlates with disease burden.
  • Normalization of Tpeak-Tend post-revascularization indicates treatment efficacy.